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Unfortunately, however, we’ll probably never have an RCT on cellphones and cancer in humans. It’d be too difficult and too expensive to randomly assign particular levels of cellphone use to thousands of people and have them stick with those plans for enough time (we’re talking at least five years) to figure out whether certain types of phones or phone use patterns cause cancer to develop. That’s not to mention the fact it’d be nearly impossible to find a group of people willing to not use cellphones and then make sure they actually stick to their promise.
“Epidemiological studies are targets for fixing the outcome because they’re observational in nature instead of experimental,” Dr. Carlo explains. “It’s possible to design studies with pre-determined outcomesthat still fall within the range of acceptable science. Thus, even highly flawed epidemiological studies can be published in peer-reviewed journals because they’re judged against a pragmatic set of standards that assume the highest integrity among the investigators.”
We really do not recommend any kind of chip, guard, anti-radiation "filters" or incomplete shielding case because honestly, how could they NOT provide a false sense of security? Folks could believe these products make them “invincible” against radiation so they are comfortable holding the case right up to their heads-and the radiation seeping from the back and the side of the phone case is in very close proximity to their precious brains. Oh no!
The studies are notable for their sizes. Researchers at the National Toxicology Program, a federal interagency group under the National Institutes of Health, tested 3,000 rats and mice of both sexes for two years—the largest investigation of RF radiation and cancer in rodents ever undertaken in the U.S. European investigators at the Ramazzini Institute in Italy were similarly ambitious; in their recent study they investigated RF effects in nearly 2,500 rats from the fetal stage until death.
But not everyone is unconcerned. In May 2015, a group of 190 independent scientists from 39 countries, who in total have written more than 2,000 papers on the topic, called on the United Nations, the World Health Organization, and national governments to develop stricter controls on cell-phone radiation. They point to growing research—as well as the classification of cell-phone radiation as a possible carcinogen in 2011 by the International Agency for Research on Cancer, part of the WHO—suggesting that the low levels of radiation from cell phones could have potentially cancer-causing effects.
First, studies have not yet been able to follow people for very long periods of time. When tumors form after a known cancer-causing exposure, it often takes decades for them to develop. Because cell phones have been in widespread use for only about 20 years in most countries, it is not possible to rule out future health effects that have not yet appeared.

DefenderShield Cellphone Radiation Case also claims independent testing and says in their website: That a "sophisticated layering of separate non-toxic, human safe materials processed for maximum radiation blocking efficiency. Each material has unique and targeted radiation-shielding characteristics designed to work in unison to eliminate all radiation emissions from 0 to 10 GHZ and Defender Shield technology refracts, conducts and finally absorbs all these potentially harmful emissions."  In this demonstration, the radiation level measured when DefendeShield case was on is still quite a bit above the level of exposure that I would recommend. I personally do not recommend-holding a phone with a shielding case to your head as the DefenderShield website shows a young woman doing as she demonstrates the product. 
It’s true that cellphones do emit radiation. And radiation is a scary word for a lot of people, thanks in part to the horrific aftermath of nuclear accidents and photographs of victims of the nuclear bombs the US dropped on Japan in World War II. People hear radiation and they associate it with nuclear radiation and the bomb, says Geoffrey Kabat, a cancer epidemiologist at the Albert Einstein College of Medicine and author of the book Getting Risk Right. “There are all these associations and those are deeply ingrained in people. But it doesn’t apply here.”
Launched at the U.S. Food and Drug Administration’s request 10 years ago, the NTP study dosed rats and mice of both sexes with RF radiation at either 1.5, 3 or 6 watts of radiation per kilogram of body weight, or W/kg. The lowest dose is about the same as the Federal Communications Commission’s limit for public exposure from cell phones, which is 1.6 watts W/kg. The animals were exposed nine hours a day for two years (about the average life span for a rat), and the exposures were cranked up steadily as the animals grew, so the absorbed doses per unit body weight remained constant over time.
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The energy of electromagnetic radiation is determined by its frequency; ionizing radiation is high frequency, and therefore high energy, whereas non-ionizing radiation is low frequency, and therefore low energy. The NCI fact sheet Electromagnetic Fields and Cancer lists sources of radiofrequency radiation. More information about ionizing radiation can be found on the Radiation page.