Manufacturers conduct government-required certification tests using a bare phone, set to transmit at maximum power, with no accessories. The recorded maximum SAR is reported to the FCC and listed in the phone’s manual. A phone tested with accessories under the same conditions can produce a higher SAR because the materials surrounding the antenna can affect the amount of radiation that reaches and is absorbed by the user’s body. A case can influence both the overall amount of emitted radiation and how it is directed.
DefenderShield Cellphone Radiation Case also claims independent testing and says in their website: That a "sophisticated layering of separate non-toxic, human safe materials processed for maximum radiation blocking efficiency. Each material has unique and targeted radiation-shielding characteristics designed to work in unison to eliminate all radiation emissions from 0 to 10 GHZ and Defender Shield technology refracts, conducts and finally absorbs all these potentially harmful emissions."  In this demonstration, the radiation level measured when DefendeShield case was on is still quite a bit above the level of exposure that I would recommend. I personally do not recommend-holding a phone with a shielding case to your head as the DefenderShield website shows a young woman doing as she demonstrates the product. 
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The effect of mobile phone radiation on human health is a subject of interest and study worldwide, as a result of the enormous increase in mobile phone usage throughout the world. As of 2015, there were 7.4 billion subscriptions worldwide, though the actual number of users is lower as many users own more than one mobile phone.[1] Mobile phones use electromagnetic radiation in the microwave range (450–3800 MHz and 24-80GHz in 5G mobile). Other digital wireless systems, such as data communication networks, produce similar radiation.
Unfortunately, regulatory boards do not require third-party phone accessory manufacturers to consider how their product will work in tandem with the smartphone. Neither do governments require smartphone manufacturers to conduct extensive research on whether their SAR will still meet the FCC’s allowable radiation exposure limits when their devices are using a phone case or other 3rd party accessories.
But scientists disagree on how real—or how serious—these risks really are, and studies have not established any definitive links between health problems and radiofrequency (RF) energy, the type of radiation emitted by cell phones. “This document is intended to provide guidance for people who want to reduce their own and their families’ exposure to RF energy from cell phones,” the guidelines state, “despite this uncertainty.”
Until the FCC establishes testing procedures that fully correspond to real-world cell phone use and reviews its radiation standards to ensure that they are fully protective for all users, including young children, EWG advises phone users to adopt these simple measures to minimize radiation exposure: Use a headset, keep the phone away from the body and text rather than talk.  
Specifically, we looked for studies that measured rates of acoustic neuromas, gliomas, meningiomas, and thyroid cancers. We also narrowed our search to studies that looked at the effect of radio-frequency radiation originating from an actual cellphone, rather than experimental equipment. We did this because we wanted evidence that could apply to real life, not specific laboratory settings or hypothetical outcomes.
We tested a variety of cellphone cases and garment shielding products including the Safe Sleeve, Defender Shield, RF Safe  cellphone “flip” cases, and the Pong cellphone case which does not have a cover over of the face of the phone. We also tested the Belly Armor blanket, nursing cover and boxers as well as an anti-radiation tank top sold by OurSure on Amazon.
Some people might consider choosing a phone with a low SAR value. Different models of phones can give off different levels of RF waves. But as noted above, according to the FCC the SAR value is not always a good indicator of a person’s exposure to RF waves during normal cell phone use. One way to get information on the SAR level for a specific phone model is to visit the phone maker’s website. The FCC has links to some of these sites here: www.fcc.gov/encyclopedia/specific-absorption-rate-sar-cellular-telephones. If you know the FCC identification (ID) number for a phone model (which can often be found somewhere on the phone or in the user manual), you can also go to the following web address: www.fcc.gov/oet/ea/fccid. On this page, you will see instructions for entering the FCC ID number.
To be fair I haven’t tried every single one on the list, but that just be careful in investing your sense of security, let alone good health, in a misplaced sense of something working just because someone says it does and they have “studies” to prove it. Every single company now claims “independently scientific studies” where as this is just usually falsified information and a marketing tactic.

Unfortunately, however, we’ll probably never have an RCT on cellphones and cancer in humans. It’d be too difficult and too expensive to randomly assign particular levels of cellphone use to thousands of people and have them stick with those plans for enough time (we’re talking at least five years) to figure out whether certain types of phones or phone use patterns cause cancer to develop. That’s not to mention the fact it’d be nearly impossible to find a group of people willing to not use cellphones and then make sure they actually stick to their promise.
The electromagnetic spectrum is broken up into two parts based on whether small doses of that radiation can cause harm: ionizing radiation and non-ionizing radiation. Ionizing radiation—UV, x-rays, and gamma rays—has enough energy in one photon (quantized minimum packet of light) to remove electrons from atoms or break apart chemical bonds. It is because of this potential for cancer-causing DNA damage that you wear a lead vest when you get x-rays at the dentist and you are advised to wear sunblock when you go out in the sun. One can’t avoid natural (radon, cosmic rays when you are up in an airplane) and man made (diagnostic x-rays) sources of ionizing radiation completely, but it is reasonable advice to minimize exposure when possible.
EWG urges the FCC to include third party-produced cases and accessories in its cell phone testing policies to ensure that they do not compromise cell phone function and do not prevent a cell phone from complying with the Commission’s exposure limits. Manufacturers should publish the radiation data for a given phone when used directly next to the body and when used with the cases most commonly sold for a specific model.
“One thing all these conditions have in common is a disruption, to varying degrees, of intercellular communication. When we were growing up, TV antennas were on top of our houses and such waves were up in the sky. Cell phones and Wi-Fi have brought those things down to the street, integrated them into the environment, and that’s absolutely new. The recognition mechanism, where protein vibration sensors on the cell membrane pick up a signal and interpret it as an invader, only works because the body recognizes something it’s never seen before.”
Forced to take action, the cell phone industry set up a non-profit organization, Wireless Technology Research (WTR), to perform the study. Dr. Carlo developed the program outline and was asked to head the research. Oversight of the issue was charged to the FDA, though it could have and probably should have gone to the Environmental Protection Agency (EPA), which fought hard for jurisdiction. But the industry had enough influence in Washington to get whatever overseer it wanted. It simply didn’t want to tangle with EPA because, says Dr. Carlo, “… the EPA is tough.”
Third, most of the studies published so far have focused on adults, rather than children. (One case-control study looking at children and teens did not find a significant link to brain tumors, but the small size of the study limited its power to detect modest risks.) Cell phone use is now widespread even among younger children. It is possible that if there are health effects, they might be more pronounced in children because their bodies might be more sensitive to RF energy. Another concern is that children’s lifetime exposure to the energy from cell phones will be greater than adults’, who started using them at a later age.
Several studies have investigated the other health effects (other than cancer) of mobile phone usage on human health. Hypotheses connecting mobile phone use to effects such as headaches, fatigue, sleep disorders, memory, vision or hearing impairment, have not been proven in established studies. A connection with reduced fertility has also not been scientifically proven.
The NTP studied radiofrequency radiation (2G and 3G frequencies) in rats and mice (33, 34). This large project was conducted in highly specialized labs that specified and controlled sources of radiation and measured their effects. The rodents experienced whole-body exposures of 3, 6, or 9 watts per kilogram of body weight for 5 or 7 days per week for 18 hours per day in cycles of 10 minutes on, 10 minutes off. A research overview of the rodent studies, with links to the peer-review summary, is available on NTP website. The primary outcomes observed were a small number of cancers of Schwann cells in the heart and non-cancerous changes (hyperplasia) in the same tissues for male rats, but not female rats, nor in mice overall.
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