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The only consistently recognized biological effect of radiofrequency radiation in humans is heating. The ability of microwave ovens to heat food is one example of this effect of radiofrequency radiation. Radiofrequency exposure from cell phone use does cause heating to the area of the body where a cell phone or other device is held (e.g., the ear and head). However, it is not sufficient to measurably increase body temperature. There are no other clearly established effects on the human body from radiofrequency radiation.

Mobile devices work by sending radio waves in the air. And while the National Cancer Institute has pointed out that the radio-frequency (RF) energy cell phone emits is low, it does not discount the possible long term health risks it poses. Some of the most recent smartphones (such as the iPhone 7 in particular), release a higher level of radiation than older cellphones; and with people spending more and more time on their devices, it’s only a matter of time before adverse effects might catch up.
Because of inconsistent findings from epidemiologic studies in humans and the lack of clear data from previous experimental studies in animals, in 1999 the Food and Drug Administration nominated radiofrequency radiation exposure associated with cell phone exposures for study in animal models by the U.S. National Toxicology Program (NTP), an interagency program that coordinates toxicology research and testing across the U.S. Department of Health and Human Services and is headquartered at the National Institute of Environmental Health Sciences, part of NIH.
A decline in male sperm quality has been observed over several decades.[11][12][13] Studies on the impact of mobile radiation on male fertility are conflicting, and the effects of the radiofrequency electromagnetic radiation (RF-EMR) emitted by these devices on the reproductive systems are currently under active debate.[14][15][16][17] A 2012 review concluded that "together, the results of these studies have shown that RF-EMR decreases sperm count and motility and increases oxidative stress".[18][19] A 2017 study of 153 men that attended an academic fertility clinic in Boston, Massachusetts found that self-reported mobile phone use was not related to semen quality, and that carrying a mobile phone in the pants pocket was not related to semen quality.[20]
SafeSleeve was founded in California by two Engineering graduates (University of Cal Poly San Luis Obispo) Cary and Alaey, with a desire to make a difference. They wanted to develop a product to help simplify, protect, and enhance the lives of their increasingly busy, tech dependent peers, family and friends. This is apparent in the highly efficient and useful, yet stylish designs and branding of SafeSleeve products. 
Most of these early studies did not find an increase in the risk for developing tumors among mobile phone users. The main problem characterizing these studies stems from the fact that the development of cancer (in particular brain tumors) takes a very long time (at least 10-20 years and up to 40 years or more), while mobile phone technology is relatively new (as aforesaid, popular use began only in the mid-90s). Hence, these studies could not demonstrate risk even if such existed.
Some studies have found a possible link. For example, several studies published by the same research group in Sweden have reported an increased risk of tumors on the side of the head where the cell phone was held, particularly with 10 or more years of use. It is hard to know what to make of these findings because most studies by other researchers have not had the same results, and there is no overall increase in brain tumors in Sweden during the years that correspond to these reports.
It’s also possible that longer-term studies and cancer incidence tracking will find larger cancer effects in another five or 10 years — or that how we use cellphones is evolving such that the devices may cause cancer in ways these studies didn’t account for. (These days, many people text instead of talking, and hold their cellphones in their pockets but not on their heads and necks.) That’s why some people look to animal studies to supplement our understanding of the potential biological effects of cellphones.
Today, the computer and phone have merged into one device that fits in the palm of your hand. A smartphone is essentially a small computer, yet has many times the computing power of traditional computers. There are no cords to connect you to a base. When turned on in your pocket or being used against your head, the cell phone touches some of the most sensitive parts of the body. Although the cell phone produces lower levels of radiation then past computers, they are now used much closer to the body and for longer periods of time, thus creating more health risks than in the past.
Since speaking with Samet, further details came out from a large study that beamed high levels of phone radiation at rats and mice. While there remain quirks in the findings, the latest evidence still doesn’t find a link between phone radiation and cancer. In response, the FDA said, “Taken together, all of this research ... [has] given us the confidence that the current safety limits for cell phone radiation remain acceptable for protecting the public health.”
Several nations have advised moderate use of mobile phones for children.[45] A journal by Gandhi et al. in 2006 states that children receive higher levels of Specific Absorption Rate (SAR). When 5- and 10-year olds are compared to adults, they receive about 153% higher SAR levels. Also, with the permittivity of the brain decreasing as one gets older and the higher relative volume of the exposed growing brain in children, radiation penetrates far beyond the mid-brain.[46]
It also means regulators need to make sure their policies reflect new levels of exposure. The Federal Communications Commission currently oversees cellphone safety and sets the limits for how much radiation people should be exposed to. (This is measured by the specific absorption rate — the rate at which the body absorbs radio frequency energy — and the current limit for cellphones is 1.6 watts of energy per kilogram of tissue. The whole-body threshold is a SAR value of 0.08 watts per kilogram, and the tower radiation limit is 10 watts per square meter.)
A study by the Corporate EME Research Laboratory and Motorola Florida Research Laboratories tested 9 different cell phone radiation shields, 5 of which claimed to block 99% of cell phone radiation. The other 4 shields tested claimed to emit a reverse radiation that would cancel out the harmful radiation from cell phones. The study found that all of the radiation shields had no effect on the amount of radiofrequency radiation a cell phone user is exposed to from their phone.[2]
I really want to caution you to be careful of any "expert" or EMF blogger recommending anti-radiation filtering cases, stickers that attach to the phone or necklaces to "ward off" EMF.  I get it, when I first realized 25 years ago that I was sensitive to electromagnetic energy and then later, when I understood that without a doubt, man made electromagnetic radiation has a biological effect on my body, I wanted an easy fix.  I tried the shielding materials and cases and I just did not feel any better.  Then I bought meters to see if the energy changed and I actually noticed what the California Department of Health now says and it's what the FTC and FCC post warnings about:  "Some shielding materials can make exposures worse". So please, be careful and read on for what you can do to avoid electromagnetic radiation exposure.
Forward your cell phone to landlines whenever you are at home, then power off the cell phone without missing a call. Biological effects can be related to both strength of cell phone radiation dose and duration of exposure, so consider whether or not your communication is urgent. Remember: Use a corded home landline (not a home cordless phone, because cordless phones use electromagnetic microwave technology just like cell phones). Most cordless phone base stations constantly emit microwave radiation regardless whether or not any connected handset is in use. The cordless phone handsets also emit microwave radiation. Corded landlines have no radiation emissions and are the best choice.
In 2007, Dr Devra Davis founded non­profit Environmental Health Trust to provide basic research and education about environmental health hazards. Dr Davis served as the President Clinton appointee to the Chemical Safety and Hazard Investigation Board in the U.S.A. from 1994–­1999, an independent executive branch agency that investigates, prevents and mitigates chemical accidents.
Cell-phone designs have changed a lot since the studies described above were completed. For example, the antennas—where most of the radiation from cell phones is emitted—are no longer located outside of phones near the top, closest to your brain when you talk, but are inside the phone, and they can be toward the bottom. As a result, the antenna may not be held against your head when you’re on the phone. That’s important because when it comes to cell-phone radiation, every milli­meter counts: The strength of exposure drops dramatically as the distance from your body increases.
It also means regulators need to make sure their policies reflect new levels of exposure. The Federal Communications Commission currently oversees cellphone safety and sets the limits for how much radiation people should be exposed to. (This is measured by the specific absorption rate — the rate at which the body absorbs radio frequency energy — and the current limit for cellphones is 1.6 watts of energy per kilogram of tissue. The whole-body threshold is a SAR value of 0.08 watts per kilogram, and the tower radiation limit is 10 watts per square meter.)
Limit your (and your children’s) cell phone use. This is one of the most obvious ways to limit your exposure to RF waves from cell phones. You may want to use your cell phone only for shorter conversations, or use it only when a conventional phone is not available. Parents who are concerned about their children’s exposure can limit how much time they spend on the phone.
The NTP studied radiofrequency radiation (2G and 3G frequencies) in rats and mice (33, 34). This large project was conducted in highly specialized labs that specified and controlled sources of radiation and measured their effects. The rodents experienced whole-body exposures of 3, 6, or 9 watts per kilogram of body weight for 5 or 7 days per week for 18 hours per day in cycles of 10 minutes on, 10 minutes off. A research overview of the rodent studies, with links to the peer-review summary, is available on NTP website. The primary outcomes observed were a small number of cancers of Schwann cells in the heart and non-cancerous changes (hyperplasia) in the same tissues for male rats, but not female rats, nor in mice overall.
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